Antibody-Mediated Rejection (without the antibodies) in Heart Transplantation

Key Points

• Antibody-mediated rejection affects graft survival despite the absence of detectable antibodies, leading to compromised cardiac function.
• Findings indicate that immune responses can still occur in heart transplantation without antibodies, which may challenge current paradigms in transplantation science.
• Observational analysis evaluated graft outcomes in heart transplant recipients over a specified duration, considering various immune response factors.
• This insight may enable the development of new strategies to improve heart transplant outcomes and enhance graft survival.