Repeated CTP showed no systematic group-level scan-to-scan bias suggestive of infarct growth, while a substantial degree of variability was observed, with intensity-based metrics demonstrating lower variability than volume estimates. These findings support temporal consistency of perfusion-derived metrics at the group level and question the applicability of linear infarct growth rate (IGR) concepts to perfusion imaging, which primarily reflects a hemodynamic state rather than time-dependent tissue progression.
Rau et al. (Tue,) studied this question.