Omics-guided discovery and functional profiling of Da-29, a bioactive serine protease from Deinagkistrodon acutus venom, with antithrombotic activity

Key Points

• Da-29, a bioactive serine protease, shows significant antithrombotic activity.
• Functional profiling revealed its effectiveness in preventing blood clot formation in vitro.
• Analysis utilized omics technology to identify and characterize the venom-derived protease.
• Findings suggest that Da-29 could lead to new treatments for thrombotic disorders.