Cancer-associated fibroblasts promote immune evasion in pancreatic cancer via miR-181b-5p/STING/LGALS1 pathway

Key Points

• Immune evasion occurs via the mir-181b-5p/STING/LGALS1 pathway, establishing a critical mechanism of tumor progression.
• Key findings include that cancer-associated fibroblasts significantly enhance immune evasion markers in pancreatic cancer samples.
• Analysis of tumor microenvironments indicates a direct relationship between fibroblast activity and immune suppression.
• These findings suggest that targeting this pathway may provide new therapeutic strategies in pancreatic cancer treatment.