Ivermectin and Doxycycline combination as a promising anti-viral drug candidate: an in-silico and DFT study

Key Points

• The combination of ivermectin and doxycycline demonstrates significant anti-viral properties, which may enhance treatment efficacy.
• Key evidence shows a substantial interaction energy of -7.80 kcal/mol, indicating strong binding affinity between the compounds.
• In-silico analysis and density functional theory modeling were utilized to evaluate the drug interaction mechanisms and potential efficacy.
• Supports the need for further investigations into this drug combination; further in-vivo studies are essential to validate findings.