The miR-378a-3p/SLC7A11 axis mediates benzoapyrene-induced ferroptosis in hippocampal neuronal cells

Key Points

• Ferroptosis is significantly induced by benzo[a]pyrene exposure in hippocampal neuronal cells, leading to cell damage.
• Notably, the modulation of the miR-378a-3p/SLC7A11 axis plays a crucial role in this process, showing a strong link.
• This analysis used experimental assessments of neuronal cell lines to observe ferroptosis mechanisms triggered by environmental toxins.
• Understanding this axis may highlight new intervention strategies for neurodegenerative diseases linked to oxidative stress.