Microbial-derived 2,3-butanediol restores epidermal barrier integrity through NF-κB signaling pathway inhibition and enhanced keratinocyte differentiation

Key Points

• Restoration of epidermal barrier integrity is achieved through inhibition of the NF-κB signaling pathway.
• Seventy-five percent of keratinocytes showed improved differentiation after treatment with 2,3-butanediol.
• Analysis demonstrates that microbial-derived 2,3-butanediol effectively enhances skin barrier function and keratinocyte health.
• Findings suggest potential therapeutic applications for protecting skin from damage and improving overall skin health.