Actinides (III) complexation by a Lanthanide Binding Tag grafted on Calmodulin N-ter domain

Key Points

• Complexation of actinides was demonstrated using a specific binding tag on calmodulin's N-ter domain, enhancing our understanding of molecular interactions.
• Data revealed that the binding efficiency of these actinides was significantly influenced by the structural configuration of the lanthanide binding tag, promoting stronger bonds.
• Analysis utilized molecular dynamics simulations to evaluate the interaction strengths between actinides and calmodulin, fostering deeper insights into ligand behavior.
• Findings imply potential applications in biochemistry for targeting specific actinides, allowing for improved strategies in environmental and medical fields.