The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis | Synapse
March 3, 2026Open Access
The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis
Key Points
Imp1 upregulation significantly enhances goblet cell maturation and mucus fucosylation during necrotizing enterocolitis (NEC).
Increased activity of Spdef plays a key role in promoting improved goblet cell function in the context of NEC.
Analysis involved assessing the biological functions of Imp1 in relation to Spdef within NEC pathology.
Findings highlight the importance of the Imp1-Spdef pathway in mucus production, suggesting targets for NEC interventions.
Abstract
Our data indicate that during NEC, upregulation of Imp1 promotes goblet cell function via Spdef, including enhanced goblet cell maturation and mucus fucosylation.