March 3, 2026Open Access

Hepatitis B virus RNA and hepatitis B surface antigen kinetics predict treatment outcomes in children with chronic hepatitis B

Key Points

HBeAg seroconversion can be better predicted by early pgRNA kinetics in children.
HBsAg loss is forecasted more effectively with HBsAg dynamics along with patient age data.
Utilizing both pgRNA and HBsAg monitoring may enhance treatment personalization in chronic hepatitis B cases.
This strategy highlights the potential for improved management and outcomes in pediatric hepatitis B therapy.

Abstract

Early pgRNA kinetics more accurately predict HBeAg seroconversion, whereas HBsAg dynamics forecast HBsAg loss more effectively, particularly when combined with patient age. This complementary monitoring strategy provides a clinically applicable tool for optimizing personalized management in children with CHB.

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Cite This Study

Peng et al. (Tue,) studied this question.

synapsesocial.com/papers/69a765bcbadf0bb9e87da389 https://doi.org/https://doi.org/10.3389/fcimb.2026.1746541

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