Oxidative stress activates HIF-1α to mediate the secretion of CXCL9 and CXCL10 in keratinocytes and trigger the abnormal immune response in vitiligo

Key Points

• Oxidative stress leads to increased secretion of CXCL9 and CXCL10 in keratinocytes, triggering immune response.
• Key evidence shows elevated levels of CXCL9 and CXCL10 correlated with oxidative stress markers.
• Analysis indicates activation of HIF-1α is critical for mediating the secretion in keratinocytes.
• Findings highlight the potential role of oxidative stress in the pathogenesis of vitiligo.