M2 macrophage-derived exosomes delivering haptoglobin and interleukin-10 plasmids for synergistic therapy of intracerebral hemorrhage

Key Points

• M2 macrophage-derived exosomes effectively deliver plasmids for haptoglobin and interleukin-10.
• The combination therapy significantly reduces inflammation and promotes healing in intracerebral hemorrhage models.
• Assessment using exosome-mediated delivery approaches and plasmid incorporation strategies demonstrates potential efficacy.
• Findings support the application of exosome therapy in brain injuries; further clinical studies needed.