March 3, 2026Open Access

Comparative evaluation of practical in-vitro methods for testing synergy between ceftazidime-avibactam and aztreonam against metallo-β-lactamase and serine carbapenemase-producing Enterobacterales species

Key Points

Significant synergy was observed with the combination of ceftazidime-avibactam and aztreonam.
Using practical methods, such as disk replacement and inverse D-zone, proved effective.
These methods are suitable for routine testing in resource-limited settings, enhancing treatment options.
Highlighting the combination's effectiveness may lead to better management of antibiotic resistance.

Abstract

The combination of CZA and ATM demonstrated significant synergistic results in MBL and serine carbapenemase-producing Enterobacterales species. The disk replacement and inverse D-zone methods are feasible and cost-effective for CZA and ATM synergy testing in routine AST within resource-limited settings, guiding treatment decisions.

Comparative evaluation of practical in-vitro methods for testing synergy between ceftazidime-avibactam and aztreonam against metallo-β-lactamase and serine carbapenemase-producing Enterobacterales species

Key Points

Abstract

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