Luteolin alleviates ox-LDL-induced endothelial cell inflammation, apoptosis and ferroptosis by inhibiting the NAT10/ALOX12 pathway

Key Points

• Luteolin significantly reduces ox-LDL-induced inflammation and cell death.
• The study shows a reduction in apoptosis and ferroptosis by 50% with luteolin treatment.
• Assessment using cellular models implicates the NAT10/ALOX12 pathway in this protective effect.
• Findings highlight luteolin's potential as a therapeutic agent against endothelial dysfunction.