Linking Cognitive Variability and Alzheimers Disease Biomarkers by Neurocognitive Status

Key Points

• Increased IICV correlates with higher levels of amyloid, tau, and neurodegeneration in cognitively impaired older adults, highlighting a potential marker for Alzheimer's disease.
• A difference in neurocognitive status demonstrates variability that could aid in understanding Alzheimer’s progression across different populations affected by the disease.
• Assessment of amyloid and tau levels, along with neurodegeneration markers, provides important insights into cognitive function and variability among older adults.
• The need for future studies is emphasized to validate these findings in more diverse populations, which could improve understanding of Alzheimer's disease.