Genetic liability to addiction underlies comorbid bipolar and substance use disorders | Synapse
March 3, 2026Open Access
Genetic liability to addiction underlies comorbid bipolar and substance use disorders
Key Points
A genetic link underlies the connection between substance use disorders and bipolar disorder, emphasizing the role of addiction.
Substance dependence is the primary factor linking these disorders, rather than broader substance use behaviors.
Investigative analysis reveals how genetic liabilities can drive comorbidity in individuals.
Understanding this genetic relationship may lead to better treatment strategies for those with both disorders.
Abstract
By dissecting the genetic liability to SUD and SU and investigating their relationship with BIP we find a genetic link driven by substance dependence but not substance use more broadly.