Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer

Key Points

• Tumor transcription and resistance phenotypes are inferred from dual ctDNA analysis, indicating distinct cancer traits.
• Key evidence shows that 5mC/5hmC methylation patterns provide crucial insights into tumor behavior in prostate cancer.
• Integrative analysis of ctDNA methylomics and clonal reconstruction was utilized to assess cancer characteristics and dynamics.
• Highlighting clonal evolution in metastatic disease may guide future therapeutic strategies and personalized treatment approaches.