Naringin-loaded metal-organic framework biomimetic hydrogel system mitigates wear particle-induced periprosthetic osteolysis by suppressing aseptic inflammation and osteoblast apoptosis

Key Points

• Naringin-loaded metal-organic framework hydrogels significantly reduce periprosthetic osteolysis.
• The study shows a decrease in osteoblast apoptosis by 30% when using the hydrogel treatment.
• Assessment involved inflammation and apoptosis markers in controlled experimental setups over 8 weeks.
• Findings support the potential of this biomimetic system in addressing wear particle-induced osteolysis.