March 3, 2026

Beyond phenotypic differences: integrating clinical pharmacy into precision management of paediatric-onset bronchiectasis

Key Points

Paediatric-onset bronchiectasis presents a unique disease burden that demands specific clinical approaches, particularly for treatment.
Of the 1422 adults studied, differences in characteristics between paediatric-onset and adult-onset bronchiectasis were notably highlighted, showing distinct clinical needs.
This prospective multicentre study emphasizes integrating clinical pharmacy practices with evidence-based medicine for better management strategies.
Ultimately, incorporating clinical pharmacy can enhance patient outcomes, highlighting the need for tailored approaches to paediatric patients.

Abstract

Extract We read with great interest the prospective multicentre study by Khalaili et al. 1, which for the first time systematically compared the clinical characteristics between paediatric-onset bronchiectasis (POBE) and adult-onset bronchiectasis (AOBE) in 1422 adult patients. This landmark study provides pivotal evidence for identifying the unique disease burden of POBE. Integrating the principles of clinical pharmacy practice and evidence-based medicine, we respectfully offer the following supplementary insights to further enhance the clinical applicability of these findings.

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