Transcriptomic profiling reveals T cell-mediated Glutamine immunomodulation via CD8A / LCK / LAT signaling in the liver model of piglets

Key Points

• T cell-mediated glutamine immunomodulation significantly alters liver metabolism and signaling pathways.
• Key analysis revealed a strong reliance on cd8a and lck for immune responses, especially in the liver.
• Using transcriptomic profiling, the study assessed cellular changes in response to glutamine treatment in piglets over a specified duration.
• Findings indicate that glutamine influences immune responses, suggesting new avenues for therapeutic interventions in similar conditions.