USP7 protects histone H1.2 from proteasome-mediated degradation to facilitate DNA repair and pancreatic neuroendocrine neoplasms progression

Key Points

• Histone H1.2 is protected from proteasome degradation by USP7, enhancing DNA repair functionality.
• Key evidence includes a direct correlation between USP7 levels and histone maintenance in tumor cells.
• Analysis highlights the role of USP7 in modulating histone stability, impacting cancer progression.
• This finding supports further exploration of USP7 as a therapeutic target for treating neoplasms.