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A highly promising new avenue for targeting K-RAS: The small-molecule degrader XMU-MP-9 | Synapse
March 3, 2026
Open Access
A highly promising new avenue for targeting K-RAS: The small-molecule degrader XMU-MP-9
JJ
Jian Jin
Icahn School of Medicine at Mount Sinai
Key Points
XMU-MP-9 effectively targets K-RAS, impacting cancer progression and treatment outcomes.
The study shows a significant reduction in K-RAS levels by the small-molecule degrader.
Assessment using in vitro experiments demonstrated the efficacy of XMU-MP-9 against cancer cells.
These findings highlight the need for further clinical trials to validate this treatment approach.
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Jian Jin (Sun,) studied this question.
synapsesocial.com/papers/69a7679fbadf0bb9e87e1b35
https://doi.org/https://doi.org/10.1016/j.apsb.2026.01.012
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