Significance of busulfan administration route including therapeutic drug monitoring in the conditioning regimen of pediatric patients prior to hematopoietic stem cell transplantation

Key Points

• Busulfan administration routes influence treatment outcomes in pediatric patients undergoing hematopoietic stem cell transplantation.
• The analysis reveals significant variability in drug levels when using different administration routes for busulfan.
• Assessment used therapeutic drug monitoring to optimize conditioning regimens before transplantation.
• Supports the need for tailored conditioning protocols, highlighting the importance of administration route and monitoring.