Identification of toxic substances considering circadian disruption: an integrated approach combining reduced transcriptomic analysis, behavioral monitoring, and time-course gene expression profiling

Key Points

• Circadian disruption significantly impacts gene expression and behavior, demonstrating the need for further exploration.
• Key findings include altered transcriptomic profiles in response to various toxic substances over time, indicating complex interactions.
• Assessment combines reduced transcriptomic analysis with behavioral monitoring, providing a comprehensive view of the effects on biological rhythms.
• Understanding these toxic effects may enable strategies for reducing health risks associated with circadian disruptions.