Exposomics has become a leading framework for examining how lifelong environmental exposures shape human health. We draw on historical and philosophical scholarship to situate its political epistemology and outline possible future paths. Historically, exposomics fits within a neo-Hippocratic tradition that links knowledge of environments and health to political priorities and interventions. Within this frame, two political epistemologies emerge: an internalist approach focused on biological tracking of environmental effects, and an integrative approach encompassing broader social and environmental layers. Both face notable epistemic and political limits. Drawing on analogical historical and contemporary cases, we identify three potential trajectories for exposomics – techno-solutionism, evidential pluralism, and fundamental-cause reasoning – each presenting distinct opportunities and challenges.
Bonnin et al. (Wed,) studied this question.