Generative AI powered by nucleic acid language model enables one-round evolution of RNA aptamers

Key Points

• One-round evolution of RNA aptamers was facilitated by a nucleic acid language model, leading to significant advancements.
• The new generative AI approach outperformed traditional methods, showing marked improvement in aptamer performance metrics.
• Analysis using a novel language model indicates potential for rapid aptamer generation in various biotechnological applications.
• This work highlights the transformative impact of AI in molecular biology and calls for further exploration in real-world applications.