GHSR1A blockade by JMV2959 following memory retrieval disrupts reconsolidation and suppresses heroin-seeking behavior

Key Points

• Blockade of ghsr1a disrupts memory reconsolidation, leading to reduced heroin-seeking behavior.
• JMV2959 administration significantly decreased drug-seeking actions in tested subjects.
• Observational analysis of memory retrieval following JMV2959 treatment reveals its effects on behavior.
• Findings may enable future treatments targeting addiction and memory processes through ghsr1a modulation.