Does selective ROCK2 inhibition reduce myocardial infarction and microvascular obstruction after ischaemia and reperfusion?
Selective ROCK2 inhibition reduces microvascular obstruction but does not limit infarct size after ischaemia and reperfusion, identifying ROCK2 as a specific microvascular target.
Dual ROCK1/2 inhibition protects myocardium from I/R injury, whereas selective ROCK2 inhibition or deficiency does not, implicating ROCK1 in infarct limitation. In contrast, ROCK2 inhibition reduced MVO, identifying ROCK2 as a potential microvascular target.
Pearce et al. (Fri,) studied this question.