A tumor-targeting gambogic acid-loaded nanovaccine reprograms the tumor microenvironment for enhanced cancer immunotherapy

Key Points

• The research aims to evaluate the effectiveness of a gambogic acid-loaded nanovaccine in improving cancer immunotherapy.
• Developed a nanovaccine combining gambogic acid with cancer antigens and adjuvants.
• Assessed its impact on the tumor microenvironment.
• Evaluated the immunotherapeutic response in a cancer model.
• The nanovaccine significantly reprogrammed the tumor microenvironment.
• Enhanced immune response observed in comparison to traditional therapies.