What question did this study set out to answer?

This research aims to explore the connection between CSF proteomic profiles and white matter integrity in older adults, particularly concerning amyloid pathology.

March 5, 2026Open Access

CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology

Key Points

This research aims to explore the connection between CSF proteomic profiles and white matter integrity in older adults, particularly concerning amyloid pathology.
Analyzed CSF proteomic profiles in older adults with and without amyloid pathology.
Evaluated white matter integrity using advanced imaging techniques.
Assessed the relationship between biological markers and cognitive function.
Identified distinct proteomic profiles associated with white matter integrity.
Noted correlations between neuronal plasticity alterations and changes in oligodendrocyte integrity.
Demonstrated that amyloid pathology impacts these biological processes in cognitively normal individuals.

Abstract

Loss of WM integrity in the very early stages of AD seems to be related to alterations in biological processes associated with neuronal plasticity and oligodendrocyte integrity. Our findings provide new insights into the distinct biological mechanisms regulating WM integrity and its relationship with AD pathology.

Bookmark

View Full Paper

Cite This Study

Lorette et al. (Mon,) studied this question.

synapsesocial.com/papers/69a91cbed6127c7a504bfb7f https://doi.org/https://doi.org/10.1212/wnl.0000000000214675

Bookmark

View Full Paper