Molecular Landscape of Prostate Cancers with Clival Metastases

Key Points

• This research aims to explore the molecular characteristics of prostate cancers that lead to clival metastases.
• Analysis of molecular profiles of prostate cancer samples with clival metastases
• Focus on DNA damage-repair mechanisms and RAF kinase alterations
• Prostate cancers with clival metastases show enrichment for DNA damage-repair alterations
• Unique RAF kinase changes were identified, suggesting potential targets for therapy