What question did this study set out to answer?

The study aims to explore how different types of emphysema influence remodeling of pulmonary arteries in COPD.

March 8, 2026Open Access

Emphysema type-CLE or PLE- determines pulmonary arteries remodeling in COPD

Key Points

The study aims to explore how different types of emphysema influence remodeling of pulmonary arteries in COPD.
Analysis of emphysema types in COPD, focusing on morphological characteristics.
Comparison between centrilobular emphysema (CLE) and panlobular emphysema (PLE).
Examination of the effects on pulmonary arteries.
Distinct differences in pulmonary artery remodeling were observed between CLE and PLE.
Centrilobular emphysema showed preservation of some alveolar structures.
Panlobular emphysema resulted in more extensive destruction of airway structures.

Abstract

Extract Emphysema, along with small airway diseases, is a crucial component of COPD. Although the type of emphysema smokers develop is not usually considered, two emphysema types with distinct morphological and physiological characteristics might be present in COPD: centrilobular emphysema (CLE), in which the center of the acinus-respiratory bronchiole and alveolar duct are destroyed with preservation of alveoli, and panlobular emphysema (PLE), seen with α-1 antitrypsin deficiency, but also in smokers with normal levels of the protein 1. In PLE the whole acinus-respiratory bronchioles and alveoli are destroyed 2.

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Cite This Study

Turato et al. (Fri,) studied this question.

synapsesocial.com/papers/69ada836bc08abd80d5bb46e https://doi.org/https://doi.org/10.1183/23120541.00961-2025

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