What question did this study set out to answer?

The study aims to develop a smartphone-assisted method to sense methylmalonic acid, a biomarker for vitamin B12 deficiency, using an imidazole-based probe.

March 8, 2026Open Access

Smartphone-Assisted Urinary Methylmalonic Acid Sensing by an Imidazole-Based Probe via Analyte-Triggered Aggregation Mechanism

Key Points

The study aims to develop a smartphone-assisted method to sense methylmalonic acid, a biomarker for vitamin B12 deficiency, using an imidazole-based probe.
Developed an imidazole-based fluorescent probe for methylmalonic acid.
Investigated the analyte-triggered aggregation mechanism for fluorescence enhancement.
Utilized smartphone technology for real-time sensing of methylmalonic acid.
Achieved effective fluorescence response upon exposure to methylmalonic acid.
Demonstrated potential for a turn-on-based sensing mechanism with high efficiency.

Abstract

Abstract Methylmalonic acid (MMA) is a key biomarker for vitamin B12 deficiency, and its sensing via a turn-on-based fluorescence mechanism is less explored. The maximum efficiency reported is a few-fold...

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Cite This Study

Kaushik et al. (Thu,) studied this question.

synapsesocial.com/papers/69ada8a1bc08abd80d5bbcc0 https://doi.org/https://doi.org/10.1039/d5ma01483b

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