What does this research mean for the field?

A significant proportion of Candida parapsilosis isolates from burn patients in Mexico exhibit resistance to fluconazole and voriconazole, primarily associated with the Y132F variant in the ERG11 gene. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate azole resistance mechanisms in Candida parapsilosis isolated from burn patients in Mexico.

March 10, 2026Open Access

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Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis.

MGMaría de Lourdes García-HernándezInstituto Nacional de Rehabilitación LNLuis Ángel Núñez-GarcíaUniversidad Autónoma de Nuevo León JOJossué Ortiz-ÁlvarezSecretaría de Ciencia, Humanidades, Tecnología e Innovación

Key Points

To investigate azole resistance mechanisms in Candida parapsilosis isolated from burn patients in Mexico.
Isolated Candida parapsilosis strains
Conducted genomic sequencing
Performed phylogenetic analysis
C. parapsilosis was the most isolated species
Significant levels of resistance to fluconazole and voriconazole
The Y132F variant in the ERG11 gene was common among resistant isolates

Abstract

C. parapsilosis sensu stricto was the predominant species isolated, with a notable proportion exhibiting resistance to FLU and VOR. The Y132F variant in the ERG11 gene was present in most sequenced isolates.

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Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis.

Key Points

Abstract

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