What does this research mean for the field?

Physical activity reduces the risk of developing overactive bladder by slowing biological aging. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The aim is to explore how biological aging influences the relationship between physical activity and overactive bladder (OAB).

March 12, 2026Open Access

Biological aging partly mediates the association between physical activity and overactive bladder: evidence from NHANES 2007–2020

Key Points

The aim is to explore how biological aging influences the relationship between physical activity and overactive bladder (OAB).
Analyzed data from the NHANES 2007-2020 to investigate associations between physical activity and OAB.
Evaluated the mediating role of biological aging on the risk of developing OAB.
Physical activity is linked to a reduced risk of developing overactive bladder.
Biological aging is identified as a significant mediator in this relationship.
Increased physical activity correlates with lower all-cause mortality in OAB patients.

Abstract

PA could reduce the risk of developing OAB partly by slowing biological aging and decrease all-cause mortality in patients with OAB. This study emphasizes the role of PA in preventing and managing OAB and encourages further evaluation of the mechanisms and effects of behavioral interventions for OAB.

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