What question did this study set out to answer?

This research aims to explore the association between NT-proBNP levels and the risk of developing different types of heart failure.

March 12, 2026Open Access

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Associations of Serially Measured NT-proBNP With Incident Heart Failure With Reduced and Preserved Ejection Fraction

Key Result

Serial NT-proBNP measurements were more strongly associated with incident heart failure with reduced ejection fraction, especially in women.

Key Points

This research aims to explore the association between NT-proBNP levels and the risk of developing different types of heart failure.
Measured NT-proBNP levels serially over time.
Compared the association with HFrEF and HFpEF outcomes.
Analyzed gender-specific differences in associations.
Stronger association found between NT-proBNP and incident HFrEF compared to HFpEF.
This association is significantly more pronounced in women.

Structured PICO

Are serially measured NT-proBNP levels associated with incident HFrEF and HFpEF?

Intervention

Serial NT-proBNP measurements

Outcome

Incident heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fractionhard clinical

Serial NT-proBNP measurements may be a stronger predictor for incident HFrEF than HFpEF, especially in women.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Serial NT-proBNP measurements were more strongly associated with incident HFrEF than HFpEF. This stronger association with incident HFrEF was particularly pronounced in women.

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Cite This Study

Kok et al. (Sun,) reported a other. Serial NT-proBNP measurements were more strongly associated with incident heart failure with reduced ejection fraction, especially in women.

synapsesocial.com/papers/69b25abe96eeacc4fcec8be3 https://doi.org/https://doi.org/10.1016/j.mayocp.2025.08.022