Solving challenging problems in quantum chemistry is one of the most promising applications of quantum computers. Within the quantum algorithms proposed for problems in excited-state quantum chemistry, subspace-based quantum algorithms, including quantum subspace expansion (QSE), quantum equation of motion (qEOM), and quantum self-consistent equation-of-motion (q-sc-EOM), are promising for pre-fault-tolerant quantum devices. The working equation of QSE and qEOM requires solving a generalized eigenvalue equation with associated matrix elements measured on a quantum computer. Our careful analytical and numerical analysis of the standard and generalized eigenvalue problems, especially in the context of excited-state methods, shows that the errors in eigenvalues magnify drastically with an increase in the condition number of the overlap matrix when a generalized eigenvalue equation is solved in the presence of statistical sampling errors. This makes methods such as QSE unstable for errors that are unavoidable when using quantum computers. Further, at very high condition numbers of the overlap matrix, the QSE's working equation could not be solved without any additional steps in the presence of sampling errors, as it becomes ill-conditioned. It was possible to use the thresholding technique in this case to solve the equation, but the solutions achieved had missing excited states, which may be a problem for future chemical studies. We also show that excited-state methods that have an eigenvalue equation as the working equation, such as q-sc-EOM, do not have the problems associated with the condition number and could be generally more stable to errors and therefore more suitable candidates for excited-state quantum chemistry calculations using quantum computers.
Kwao et al. (Tue,) studied this question.