Multimodal skin rejuvenation with Restylane ® skin boosters non-animal stabilized hyaluronic acid: A retrospective case series of five patients

Skin aging leads to reduced elasticity, hydration, and texture quality. While hyaluronic acid (HA) fillers address volume loss, skin boosters non-animal stabilized HA (SB-NASHA), target dermal hydration and collagen support. Evidence on combining HA skin boosters with energy-based or injectable treatments in Indian skin is limited. This retrospective case series reports outcomes from five patients treated with SB-NASHA alongside tailored modalities. Five adults (three males, two females; aged 24–45 years, Fitzpatrick IV–V) presented with enlarged pores, acne scars, pigmentation, dullness, fine lines, and laxity. Patients received 3 monthly sessions of SB-NASHA (Vital, 20 mg/mL; 2 mL/session) with individualized adjunctive procedures. Injections were delivered using the SmartClick ™ system. Improvements were evaluated through the global aesthetic improvement scale, skin quality assessment, physician global evaluation, and patient ratings. All showed enhanced radiance, tone, texture, and elasticity. No adverse events occurred. SB-NASHA with complementary modalities provides effective, well-tolerated skin quality improvement in Indian skin types.