What question did this study set out to answer?

The research aims to explore the relationship between SPECT imaging and echocardiographic parameters in patients suspected of having transthyretin-related cardiomyopathy.

March 12, 2026

Correlation of global and regional quantitative 99mTc-3,3-diphosphono-1,2 propanodicarboxylicacid single-photon emission computed tomography with echocardiography in patients with suspected transthyretin-related cardiomyopathy.

Q: What does this research mean for the field?

There is a robust correlation between echocardiographic parameters and [99mTc]Tc-DPD SPECT SUVs in patients with suspected transthyretin-related cardiomyopathy (ATTR-CM). Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Key Result

A strong correlation exists between echocardiography parameters and [99mTc]Tc-DPD SPECT SUVs in patients with suspected transthyretin-related cardiomyopathy.

Key Points

The research aims to explore the relationship between SPECT imaging and echocardiographic parameters in patients suspected of having transthyretin-related cardiomyopathy.
Conducted single-photon emission computed tomography (SPECT) imaging with 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD)
Performed transthoracic echocardiography (TTE) to assess cardiac function
Compared TTE-derived parameters to 99mTc-DPD SPECT standardized uptake values (SUVs)
Found a robust correlation between echocardiography-derived parameters and 99mTc-DPD SPECT SUVs
Indicated that morphologic changes in the myocardium are linked to 99mTc-DPD uptake
Highlighted potential pathophysiological mechanisms in the progression of transthyretin-related cardiomyopathy (ATTR-CM)

Structured PICO

Does quantitative [99mTc]Tc-DPD SPECT correlate with echocardiography parameters in patients with suspected transthyretin-related cardiomyopathy?

Population

Patients with suspected transthyretin-related cardiomyopathy (ATTR-CM)

Intervention

Quantitative 99mTc-3,3-diphosphono-1,2 propanodicarboxylicacid single-photon emission computed tomography ([99mTc]Tc-DPD SPECT)

Comparator

Transthoracic echocardiography (TTE)

Outcome

Correlation between TTE-derived parameters and corresponding [99mTc]Tc-DPD SPECT standardized uptake values (SUVs)surrogate

There is a robust correlation between morphologic alterations on echocardiography and [99mTc]Tc-DPD activity on SPECT in suspected ATTR-CM.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

The robust correlation found between TTE-derived parameters and the corresponding 99mTcTc-DPD SPECT SUVs supports the link between morphologic alterations and 99mTcTc-DPD activity within the myocardium, also potentially highlighting a pathophysiological mechanism involved in the progression of ATTR-CM.

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