Longitudinal changes in epigenetic age acceleration prior to type 1 diabetes onset in the Diabetes Autoimmunity Study in the Young (DAISY)
Key Points
This research aims to explore the timing of epigenetic age acceleration in children before the onset of type 1 diabetes.
Conducted a longitudinal study with children from the Diabetes Autoimmunity Study in the Young (DAISY) cohort.
Monitored changes in epigenetic age over time.
Assessed autoantibody seroconversion related to type 1 diabetes.
Identified epigenetic age acceleration occurring prior to the seroconversion of islet autoantibodies.
Highlighted possible connections between environmental stressors and the early onset of type 1 diabetes.
Abstract
These results suggest that EAA occurs in children who develop type 1 diabetes prior to IA seroconversion, highlighting the potential role of early environmental stressors in disease pathogenesis.