Background/Objectives: Artificial intelligence (AI) tools, particularly large language models (LLMs) such as ChatGPT-4o, are gaining prominence in medicine. While their diagnostic capabilities have been explored across various oncologic domains, their role in clinical decision-making within multidisciplinary tumor boards (MTBs) remains largely unexamined in urologic oncology. This study evaluates the performance of ChatGPT-4o as a decision-support tool in a real-world MTB setting by comparing its recommendations with those of expert clinicians. Materials and Methods: A retrospective study was conducted using 98 anonymized clinical cases discussed by a urologic MTB between June 2024 and February 2025. An independent urologist entered the same cases into ChatGPT-4o using a standardized prompt replicating real-world presentation. Two certified urologists independently assessed the model’s responses. Agreement was analyzed overall and by tumor type, disease stage, clinical context, and treatment strategy. Results: ChatGPT-4o fully agreed with the MTB in 56.1% of cases, was correct but incomplete in 23.5%, and provided partially accurate but flawed recommendations in 18.4%. Overall concordance between ChatGPT-4o and the MTB yielded a Cohen’s kappa of 0.61, indicating moderate-to-good agreement. Discrepancies were most common in metastatic prostate cancer, often due to misclassification of tumor burden or errors in treatment sequencing. Highest agreement rates were observed in bladder and renal tumors, and in standardized therapeutic scenarios such as radiotherapy. Conclusions: ChatGPT-4o demonstrated moderate alignment with expert MTB decisions and performed best in well-defined clinical contexts. While it cannot replace multidisciplinary expertise, it may serve as a supportive tool to enhance access to standardized oncologic care.
Torre-Trillo et al. (Wed,) studied this question.