What question did this study set out to answer?

To address the challenges in coculturing mammalian cells and bacteria using a microfluidics approach.

March 14, 2026Lab on a Chip0 citationsOpen Access

Multiphasic droplet microfluidics platform for controlled bacteria and mammalian cell coculture

IAIbraheem AlshareedahLos Alamos National Laboratory AKAnand KumarLos Alamos National Laboratory

Key Points

To address the challenges in coculturing mammalian cells and bacteria using a microfluidics approach.
Utilized a multiphasic droplet microfluidics platform to enable controlled coculture.
Investigated compatibility between mammalian cells and bacteria in a miniaturized environment.
Optimized growth conditions for both cell types in microfluidic systems.
Demonstrated enhanced spatial control in coculture conditions.
Achieved high-throughput biological assays using the droplet platform.
Revealed improved growth for both bacteria and mammalian cells in the designed microfluidic system.

Abstract

Microfluidics has revolutionized high-throughput miniaturized biological assays. However, coculture of mammalian cells and bacteria remains challenging in microfluidic systems due to incompatible growth requirements, limited spatial control, and the requirement...

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