Aims: Psoriasis is a persistent, immune-mediated dermatological condition shaped by both hereditary and environmental influences. The ABCG2 gene, encoding an ATP-binding cassette transporter, is involved in processes such as cellular detoxification, urate handling, and modulation of inflammatory pathways. The rs2231142 single nucleotide polymorphism (GT) in ABCG2, which reduces transporter efficiency, has been linked to several inflammatory diseases. This study sought to determine whether the rs2231142 variant is associated with psoriasis risk in a Turkish cohort.Methods: The study included 150 patients with psoriasis and 150 healthy individuals. Genotyping for rs2231142 was performed using the tetra-primer ARMS-PCR method. Data were evaluated under codominant, dominant, and allelic inheritance models.Results: A significant difference in rs2231142 genotype distribution was observed between cases and controls (TT vs. GG: OR = 1.89, 95% CI = 1.03–3.48; p = 0.040). In the dominant model (GT+TT vs. GG), the variant was also significantly related to higher psoriasis risk (OR = 1.77, 95% CI = 1.11–2.83; p = 0.017). The T allele occurred more frequently in patients (38.3%) compared to controls (27.3%), conferring increased risk (OR = 1.42, 95% CI = 1.05–1.90; adjusted p = 0.021). No statistically significant correlations were found between rs2231142 genotypes and clinical characteristics such as disease duration, Psoriasis Area and Severity Index (PASI) score, or positive family history.Conclusion: The rs2231142 polymorphism in ABCG2 appears to be associated with a greater likelihood of developing psoriasis, possibly due to reduced transporter activity and intensified inflammatory responses.
Akgün et al. (Thu,) studied this question.