What question did this study set out to answer?

The aim is to develop an electrochemical method for C(sp3)–H amination to synthesize quinazolines under mild conditions.

March 14, 2026European Journal of Organic Chemistry0 citations

Electrochemical Iodine‐Catalyzed C(sp 3 )–H Amination for the Synthesis of 2‐Arylquinazolines

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YZYupu ZhangUniversity of Science and Technology of China KLKai LiHefei National Center for Physical Sciences at Nanoscale HYHao YangHefei National Center for Physical Sciences at Nanoscale

Key Points

The aim is to develop an electrochemical method for C(sp3)–H amination to synthesize quinazolines under mild conditions.
Developed a cyclization reaction using an iodine catalyst.
Applied electrochemical techniques for amination.
Evaluated scalability and substrate applicability.
Achieved good yields of various substituted quinazolines.
Demonstrated metal-free and oxidant-free reaction conditions.

Abstract

An efficient electrochemical C(sp 3 )–H amination cyclization was developed under mild conditions in the presence of an iodine catalyst. A series of substituted quinazolines can be obtained with good yields by virtue of the new avenue. The reaction features excellent substrate applicability, scalability, metal‐free, and chemical oxidant‐free.

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Cite This Study

Zhang et al. (Wed,) studied this question.

synapsesocial.com/papers/69b4fc1fb39f7826a300cc7a https://doi.org/https://doi.org/10.1002/ejoc.202501224

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