To analyse the relationship between the occurrence of perinatal infections in neonates delivered by mothers with premature rupture of membranes(PROM) and the level of neutrophil apolipoproteins in umbilical cord blood and to investigate the level of Human neutrophil lipocalin(HNL) in umbilical cord blood of neonates with PROM and its value in the diagnosis of perinatal infections in neonates. According to the inclusion criteria, 256 patients born in Xinjiang Uygur Autonomous Region People’s Hospital between 06/2022 and 06/2023 were retrospectively screened, and the patients were divided into two groups based on whether or not infections occurred in the perinatal period of the newborns. The two groups were (1) the infected group (n = 91) and (2) the uninfected group (n = 165). Data on sex, gestational age, birth weight, Apgar score at PROM, Tumor Necrosis Factor-alpha (TNF-α), procalcitonin, HNL level, C-Reactive Protein (CRP), calcitonin (PCT), Interleukin-6 (IL-6), Interleukin-8 (IL-8), and other factors were collected and compared between the groups. These factors were first analyzed using univariate analysis. Variables with a P < 0.05 were then included in a binary logistic regression analysis to identify independent risk factors for perinatal infection. A total of 256 patients were included in this study to compare the parameters between the infected and uninfected groups. The results of univariate analysis showed that HNL level, CRP, IL-6, and IL-8 were correlated, and the difference was statistically significant (P < 0.05). Binary logistic regression identified HNL level (OR = 1.166, 95% CI: 1.105–1.256, P < 0.05), CRP (OR = 4.77, 95% CI: 2.215–14.377, P < 0.05), and IL-6 (OR = 1.25, 95% CI: 1.008–1.586, P < 0.05) as independent risk factors for perinatal infections. IL-8 was not significant in the multivariate model (OR = 1.007, 95% CI: 0.935–1.086, P = 0.845). In summary, HNL level, CRP, and IL-6 are important predictors of perinatal infections in newborns, and they have high diagnostic value in clinical diagnosis. Physicians should consider the levels of these biomarkers together with other clinical manifestations and laboratory findings to more accurately assess the risk of perinatal infections in newborns and to develop effective treatment plans. Meanwhile, for the relationship between HNL levels and perinatal infections in newborns, future studies can further explore the potential mechanism of action and clinical application value in depth. Not applicable.
Aihaiti et al. (Fri,) studied this question.