Fourier transform infrared (FTIR) spectrometry is a sustainable analytical technique widely used for quantifying pharmaceutical substances such as raw materials and dosage forms. Reports show that conventional techniques such as HPLC and UV spectrophotometry are often costly and time‐intensive, whereas the ATR‐FTIR method offers a rapid and straightforward alternative for drug analysis. This study introduces a rapid, cost‐effective, and reliable method for estimating vildagliptin (VGP) using water as a solvent for FTIR spectra acquisition. Quantification was conducted at 1439 and 1628 cm −1 , ensuring optimal analysis. Method validation followed ICH guidelines, demonstrating linearity (1–5 mcg/mL), accuracy, precision, robustness, and selectivity. The limit of detection (LOD) was 0.06 and 0.02 mcg/mL, while the limit of quantification (LOQ) was 0.201 and 0.08 mcg/mL for the respective wavenumbers. The technique showed high accuracy with minimal percentage error and relative standard deviation across intraday and interday measurements. Selectivity was confirmed by comparing standard drugs with API and tablet formulations, while robustness was maintained despite minor variations in conditions. The method was successfully applied to VGP tablet formulations. Greenness was checked out using the Analytical Greenness Calculator (AGREE) and Green Analytical Procedure Index (GAPI), both confirming its excellence as an environmentally friendly technique.
Kumar et al. (Thu,) studied this question.