Incidence of Fatty Liver and Liver Function Changes in Hormone Receptor-Positive Breast Cancer Patients upon Receiving Long-Term Postoperative Tamoxifen Therapy

Key Points

• This research aims to evaluate the impact of long-term tamoxifen therapy on liver function and the incidence of fatty liver in breast cancer patients.
• Retrospective analysis of 186 breast cancer patients treated with tamoxifen from 2008 to 2023.
• Assessment of liver function through laboratory tests including ALT and γ-GTP.
• Analysis of liver imaging findings to check for fatty liver incidence.
• Significant increase in ALT (P=0.002), γ-GTP (P<0.001), and FIB-4 index (P<0.001) was observed post-treatment.
• 67% of patients with elevated ALT were found to have fatty liver.
• No significant change in ALBI score (P=0.054) was identified.