Recent advances in live-cell imaging, super-resolution microscopy, labeling techniques and cryo-electron microscopy reveal vimentin intermediate filaments (VIFs) as adaptable polymers that couple mechanical stability with rapid remodeling. In this review, we highlight recent findings and discuss how VIFs function as dynamic, interpenetrating networks with actin microfilaments and microtubules, coordinating cytoskeletal architecture while simultaneously facilitating organelle positioning and influencing cellular behavior. We also propose a hybrid transport model to capture the diverse modes of VIF cellular interactions. This emerging framework positions VIFs as dynamic integrators of cytoskeletal organization and intracellular logistics, with broad implications for understanding cell mechanics, migration, and disease.
Renganathan et al. (Sun,) studied this question.