Gastroesophageal reflux disease (GERD), hyperacidity, and related acid-peptic disorders are commonly treated with antacids, though conventional formulations often provide limited and short-lasting relief. This study focuses on developing a semi-solid gel-based combination antacid containing sodium alginate, sodium bicarbonate, and calcium carbonate to enhance acid neutralization and patient compliance. The gel system offers faster drug release, better mucosal adhesion, and prolonged gastric retention. The formulation was evaluated for physicochemical properties, acid-neutralizing capacity (ANC), release profile, and stability, and compared with a marketed product. The findings aim to establish a more effective, patient-friendly, and cost-efficient antacid gel for improved management of acid-peptic disorders.
Narkhede* et al. (Mon,) studied this question.