HTE-enabled Discovery of Palladium-Catalysed (Hetero)Arylation of Barbituric and Meldrum's Acid

Key Points

• To explore efficient conditions for palladium-catalysed arylation of barbituric and Meldrum's acid using high-throughput experimentation.
• Utilized high-throughput experimentation to screen various reaction conditions.
• Focused on direct palladium-catalysed reactions involving unprotected barbituric acid and Meldrum's acid.
• Assessed reaction efficiency under different catalyst and solvent combinations.
• Identified favorable conditions for the arylation reactions that were previously challenging to achieve.
• Demonstrated higher yields in selected reaction setups compared to traditional methods.